Search results for "airway smooth muscle"

showing 3 items of 3 documents

Non-Canonical WNT Signaling Regulates TGF-²1-Induced Extracellular Matrix Production By Airway Smooth Muscle Cells

2012

Extracellular matrixChemistryAirway smooth muscleNon canonical wntCell biologyTransforming growth factorD28. DEVELOPMENTAL SIGNALING REBORN IN ADULT LUNG DISEASE
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Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments.

2005

Abstract Background We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. Methods We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 ± 2.2 yrs of age, mean ± SEM) undergoing lobar resection for peripheral pulmonary nodule. Prior to surgery, we measured TLCO and determined the bronchodilatory effect of deep inspiration after constricting the airways with methacholine. The number of destroyed alveolar attachments, as well as airway wall area and airway smoo…

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyPathologyStatistics as TopicBronchial provocation testsCOPD lung inflationBronchi030204 cardiovascular system & hematologySettore MED/10 - Malattie Dell'Apparato RespiratorioBronchial Provocation Tests03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicineHumansLung volumesMethacholine ChlorideAgedlcsh:RC705-779COPDbusiness.industryResearchAirway smooth musclelcsh:Diseases of the respiratory systemrespiratory systemmedicine.diseaserespiratory tract diseasesPulmonary Alveoli030228 respiratory systemMethacholine chlorideInhalationAirway wallCardiologyMethacholineFemalebusinessmedicine.drugRespiratory research
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Clinical implications of airway hyper-responsiveness in COPD

2006

COPD represents one of the leading causes of mortality in the general population. This study aimed at evaluating the relationship between airway hyperresponsiveness (AHR) and COPD and its relevance for clinical practice. We performed a MEDLINE search that yielded a total of 1919 articles. Eligible studies were defined as articles that addressed specific aspects of AHR in COPD, such as prevalence, pathogenesis, or prognosis. AHR appears to be present in at least one out of two individuals with COPD. The occurrence of AHR in COPD is influenced by multiple mechanisms, among which impairment of factors that oppose airway narrowing plays an important role. The main determinants of AHR are reduct…

Pulmonary and Respiratory MedicinePathologymedicine.medical_specialtymedicine.medical_treatmentMEDLINEPopulationReviewsSettore MED/10 - Malattie Dell'Apparato RespiratorioBioinformaticsBronchial Provocation TestsPathogenesisDiagnosis DifferentialMedical Subject HeadingsPulmonary Disease Chronic ObstructivePredictive Value of TestsmedicineRespiratory HypersensitivityCOPDHumansairway smooth muscle aging bronchial obstructioneducationLungAsthmaCOPDeducation.field_of_studyLungbusiness.industryHealth Policyairway hyperresponsivenessSmokingPublic Health Environmental and Occupational HealthGeneral Medicinerespiratory systemmedicine.diseasePrognosisAsthmarespiratory tract diseasesbronchial hyperreactivitymedicine.anatomical_structurePredictive value of testsSmoking cessationbusinessAirwayInternational Journal of Chronic Obstructive Pulmonary Disease
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